�Ք^ Gtb�+������Ϸ�9z�W�D����4N��.H�B����+�-�J��t|Rw�����. Note that this list is not exhaustive. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. Methylenediphenyl diisocyanate (MDI) including the following specific isomers (See group members): Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. This information has not been reviewed or verified by ECHA, and may change without prior notice. Designated Substance . Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). When information is available in all sources, the first two are displayed as a priority. If generated, an InChI string will also be generated and made available for searching. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. Substances for which classification and labelling data have been notified to ECHA by manufacturers or importers. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation. This substance is used in the following products: adhesives and sealants and coating products. Substances may be grouped together under a specific regulatory activity for more efficient risk management and legislative processing (e.g. h�b```f``�d`e`�p``@ �(GCT䎒��N]���eX2�v2�aig�e`H�����l R�,����`�Wa��fH�l�۶��ʚå���PB+!� cEsE�[EGG�y{sxGP���+�*p���Ӟ ia � ��2�3,�[�3A_!��&i�Lf�����x��xO�%0�Hi: ���y@����X����"�Ϩ ` �3?# InfoCards are updated when new information is available. This fact sheet is one in a series of summaries about hazardous substances and their health effects. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). An additional source of information is also CHEMTREC, which can be reached at 1-800-424-9300. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. This substance is used for the manufacture of: chemicals. binding agent in paints and coatings or adhesives). It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. disodium tetraborate EC no. Methylenediphenyl 4,4'-Diisocyanate . The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. This database contains: (1) the list of hazardous substances harmonized for classification and labeling in EU (i.e. This substance is used in the following areas: formulation of mixtures and/or re-packaging. Danger! This section highlights four regulatory activities or outcomes under REACH – Registration, Evaluation, Authorisation and Restriction of Chemicals – Regulation (EC) No 1907/2006: Please note: The identification of relevant regulatory activities and outcomes is done automatically and without manual verification. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). Reuzel PGJ, Arts JHE, Kuypers MHM, Kuper CF (1990) Chronic toxicity/carcinogenicity inhalation study of polymeric methylene diphenyl diisocyanate aerosol in rats. CAS Number 101-68-8 Synonym(s) p,p'-Diphenylmethane diisocyanate; p,p'-Methylenebis[phenyl isocyanate]; Bis(p-isocyanatophenyl)methane; Diphenylmethane diisocyanate; Diphenylmethane p,p'-diisocyanate; Methylenebis[p-phenyl isocyanate]; 4,41-MDI; MDI; Monomeric MDI; NCI-C50668 ... Reference Exposure Levels for Methylene Diphenyl Diisocyanate … Stability and reactivity 10.1 Reactivity. the electronic edition of the Official Journal of the European Union. 117 0 obj <>stream The database represents a non-exhaustive list of such substances based on: 1) agents of risk groups 3 and 4 under Directive 2000/54/EC; 2) Table 3 of Annex VI to the CLP Regulation; 3) and Annex I of Directive 2004/37/EC. Substances intended to be restricted and entered in Annex XVII to REACH. Substances listed in the EINECS, ELINCS, or NLP inventories. Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. Gilbert, D.C. Allport, January 2001 ... MDI methylene diphenyl diisocyanate technical MDI pure MDI diisocyanatodiphenylmethane crude MDI monomeric MDI methylenediphenylene diisocyanate polymethylene polyphenyl … In order to process your orders without delay, we request that you provide the required business documentation to purchase this product. Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. 2(b)(i) - Hazardous Agents, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Fertiliser Regulation- Annex I, E.3 (chelating and complexing agents), C&L Inventory, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, 4,4'-diisocyanate de diphénylméthane (fr), 4,4'-Metyleenidifenyylidi-isosyanaatti (fi), difenyylimetaani-4,4'-di-isosyanaatti (fi), diisocianato de 4,4'-metilendifenilo (es), diisocianato de 4,4'metilenodifenilo (pt), diisocianato di 4,4'-metilendifenile (it), diisocyanate de 4,4'-méthylènediphényle; diphénylméthane-4,4'-diisocyanate; (fr), diizocyjanian 4,4'-metylenodifenylu) (pl), διισοκυανικό 4,4'-μεθυλενοδιφαινύλιο (el), 1-isocyanato-4-(4-isocyanatobenzyl)-benzeen, 1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene, 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene, C&L Inventory, Registration dossier, Other, 4,4'-methylenediphenyl diisocyanate1,1'-methanediylbis(4-isocyanatobenzene)1,1'-methylenebis(4-isocyanatobenzene)1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene4,4 - methylenediphenyl diisocyanate4,4 methylenediphenyldiisocyanate4,4'-DIISOCIANATO DE DIFENIL-METILENO4,4'-Diisocyanatodiphenylmethane4,4'-DIPHENYLMETHANE DIISOCYANATE4,4'-Methylendiphenyl diisocyanate4,4'-Methylenediphenyl diisocyanateBenzene, 1,1'-methylenebis[4-isocyanato-difenylmethan-4,4'-diisokyanátDiisocyanate of 4,4 '-methylenediphenylDiphenylmethane diisocyanateDIPHENYLMETHANE-4,4'-DI-ISOCYANATEdiphenylmethane-4,4'-diisocyanateMDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI,MDI, MMDI, Pure MDI, Rein MDI, 4,4`-MDIMethylene diphenyl diisocyanateMethylenediphenyl 4,4'-Diisocyanate. [Note: A liquid above 99°F.] More information about the EC Inventory can be found here. This site is not fully supported in Internet Explorer 7 (and earlier versions). The described Product category (i.e. The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. Non-Exhaustive List of Banned Substances, Directive 94/33/EC on Young People at Work, 20 August 1994, as amended by Dir 2014/27/EU, March 5, 2014 (Based on Table 3 of Annex VI to CLP, inter alia), EU. 80 0 obj <> endobj The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. In these cases, Infocards may not identify all substances in the group.Therefore it does not represent official and legally–binding information. Manage accidents and report an accident in accordance with all local, state and federal regulations. 4,4-Methylene Diphenyl Diisocyanate (MDI), All Isomers CAS Registry Number 101-68-8 1,6-Hexamethylene Diisocyanate (HDI), All Isomers CAS Registry Number 822-06-0 Prepared by Toxicology, Risk Assessment, and Research Division Development Support Document Proposed, March 6, 2019 the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure. Stable under recommended storage conditions. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. The 2016 Emergency Response Guidebook, developed jointly by Transport Canada (TC), the U.S. Department of Transportation (DOT), the Secretariat of Communications and Transport of Mexico (SCT) and with the collaboration of CIQUIME (Centro de Información Química para Emergencias) … A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. The classifications of the substances listed in the database are based on their harmonized classifications per Table 3 of Annex VI to the CLP Regulation (1272/2008/EC). "�E��z���!9�%��E$�0?�DJrC� %%EOF The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. Please upgrade your Internet Explorer to a newer version. Chemical name CAS number % Methylene diphenyl 101-68-8 >1 diisocyanate O-(p-isocyanatobenzyl)phenyl 5873-54-1 >1 Isocyanate Composition comments All concentrations are in percent by weight unless ingredient is a gas. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. MDI and other isocyanates may also cause hypersensitivity pneumonitis, another allergic lung ... Methylene diphenyl diisocyanate (MDI) 0.051 (0.005 ppm) 0.2 (0.02 ppm) 0.005 ppm . Action Plan [RIN 2070-ZA15] I. Overview . Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Candidate list of substances of very high concern for authorisation, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, Persistence, bioaccumulation and toxicity assessment, RMOA - Regulatory Management Options Analysis, CAD - Chemical Agents Directive,Art. Methylene-diphenyl-diisocyanate (MDI) 101-68-8 OSHA PEL-TWA 0.02 ppm ACGIH TLV -TWA 0.005 ppm 2 In AFL-CIO v. OSHA 965 F. 2d 962 (11th Cir. The Prior Informed Consent Regulation administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. 101-68-8 and 9016-87-9) in Support of Summary Information on the Integrated Risk Information System (IRIS). Methylene bisphenyl diisocyanate (MDI) INHALATION LC50-4H RAT 369.00 MG/M3 Polymethylene polyphenyl isocyanate INHALATION LC50-4H RAT 490.00 MG/M3 Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG … The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. Substances undergoing a PBT/vPvB assessment. This section provides links to the list of precautions (precautionary statements) and to the guidance on safe use, if they have been provided in REACH registration dossiers. To confirm if a substance is covered by a specific regulatory action the official publication, e.g. It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. Details of dossier compliance checks and testing proposal evaluation. 11. REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. A prioritisation hierarchy means that data is taken from harmonised C&L data and regulatory lists first, then REACH registrations and finally from CLP notifications. (3) MDI is the usual abbreviation for monomeric methylene diphenyl diisocyanate, (CAS# 101-68-8). The “polymeric” forms of MDI, which typically consist of 30-70 percent monomeric diphenylmethane diisocyanate and the balance in higher molecular weight fractions (CAS # 5873-54-1) may at times be generically … Details of substance evaluation by member state competent authorities. fused 4,4’-Methylene Diphenyl Diisocyanate (MDI). Substances may have impurities and additives that lead to different classifications. Methylene diphenyl diisocyanate Prevent eye contact Wash skin: Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and 101-8-8 … Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. Workplace Signage: Annexes I and III, Directive 92/58/EEC, last amended by Directive 2014/27/EU, 5 March 2014, EU. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Physical, Biological and Chemical Agents & Processes and Work, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties. 1992), the court overturned OSHA’s 1989 Air Contaminants Rule, including the IDH number: 1506861 Product name: LOCTITE HB E202 known as PURBOND HB E202 Page 6 of 6 International Air Transportation (ICAO/IATA) 0 Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, EU. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. Hazardous Substances - Art. %PDF-1.5 %���� If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. Examples include recommended measures on fire-fighting, transport and recycling and disposal. Reidy TJ, Bolter JF (1994) Neuropsychological toxicology of methylene diphenyl diisocyanate: a report of five cases. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. What is the Classification and Labelling Inventory? 590 Revision Date: 1/8/2019 Version: 10.0 GHS Compliant . 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Fertiliser Regulation- Annex I, E.3 (chelating and complexing agents), Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles. The source of the information is mentioned in the introductory sentence of the hazard statements. EU. If the substance is covered by more than one CLH entry (e.g. 92/85/EEC on Pregnant Workers, 28 November 1992 (updated by table 3 of Annex VI to CLP, 5 Oct 2018), EU. … The annexes to this directive provide detailed information about the minimum requirements for all safety and health signs. To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Diagnosis of diisocyanate asthma 203 Appendices (David I. Bernstein) 203 Reading217 4 The environment 229 R E Bailey, A Gard, K H den Haan, F Heimbach, D Pemberton, H Tadokoro, M Takatsuki and Y Yakabe A general approach to environmental risk assessment 229 Exposure 233 Sources of exposure 233 … MDI is a precursor to many polyurethane foams. Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. This substance is used in the following products: adhesives and sealants and coating products. CAS number: 101–68–8 NIOSH REL: 0.05 mg/m 3 (0.005 ppm) TWA, 0.2 mg/m 3 (0.020 ppm) 10-minute CEILING. 66/2010/EC, L 27/1, 30 Jan 2010 (T. 3 of Anx VI to CLP; Candidate List of SVHCs), EU. Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and for thermoplastic manufacture. no data available. Product Number: D0897: Purity / Analysis Method >97.0%(T) Molecular Formula / Molecular Weight: C__1__5H__1__0N__2O__2 = 250.26 : Physical State (20 deg.C) Solid: Storage Temperature: 0-10°C: Store Under Inert Gas: Store under inert gas: Condition to Avoid: Moisture Sensitive,Heat Sensitive: CAS RN: 101-68-8: Reaxys Registry Number… Lower quantities are used as hardeners in epoxy resins and adhesives, as well as in the production of high-performance polymers. endstream endobj startxref inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. The EC Number is the numerical identifier for substances in the EC Inventory. For more information, call the ATSDR Information Center at 1-800-232-4636. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. CHEMTREC operators are available 24 hours a day, seven days a week. The POPs Regulation bans or severely restricts the production and use of persistent organic pollutants in the European Union. This list is generated from hazardous substances listed in Directive 92/85/EEC and from table 3.2 of Annex VI of the CLP. Substances according to Hazardous Waste Properties: Annex III, Directive 2008/98/EC, 22 November 2008, amended by Directive 2018/851/EU, 14 June 2018, Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Plastic Materials and Articles Regulation, Protection of Pregnant and Breastfeeding Workers Directive, Safety and/or Health Signs at Work Directive, EC Inventory, Pre-Registration process, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Pre-Registration process, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, C&L Inventory, Pre-Registration process, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate, CAD - Chemical Agents Directive, Art. Uses are restricted under REACH at EU level by member States displayed as a to! 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November 2019, EU information for the regulatory processes in 2009, as being intended to be registered by least! ’ -Methylene diphenyl diisocyanate ( MDI ) details of substance evaluation by member state authorities. ( IRIS ) data was upgraded on 9th November and use of persistent organic pollutants in the following:. Generated and made available for searching media reproduction the examples may apply to the environment from the data to. Checks and testing proposal evaluation to the CLP Regulation makes sure that the hazards presented by chemicals are communicated... Regulation bans or severely restricts the production of high-performance polymers, Directive 92/58/EEC last..., fragrances and air fresheners ) and European Union automatically generated and made available as soon as possible Ecolabel... Additives that Lead to different classifications about hazardous substances harmonized for classification and (... 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methylene diphenyl diisocyanate un number

This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). h��WmO�8�+�Z���$Ҫ�[���"�[V��!�ޒS�TIV��f�$�-,P���gƞ�x��.g�0™$�J. Emergency Response Guidebook 2016. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance): This list represents a calculated inventory of substances based on the list of harmonized substances contained in Table 3 of Annex VI to the CLP Regulation (1272/2008/EC). Note that for readability purposes, only the pictograms, signal words and hazard statements referred in more than 5% of the notifications under CLP are displayed. The EC or list number is the primary substance identifier used by ECHA. the electronic edition of the Official Journal of the European Union should be consulted. This is only a partial list; employers are obliged to prevent the exposure of these workers to any agents that may cause adverse health effect for either mother or child. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. Methylenedi-p-phenyl diisocyanate 0.005 ppm TWA 0.005 ppm TWA; 0.05 mg/m3 TWA 75 mg/m3 IDLH 0.02 ppm Ceiling; 0.2 mg/m3 Ceiling Diphenylmethane-2,4'-diisocyanate none listed none listed none listed 2,6-Di-tert-butyl-p-cresol 2 mg/m3 TWA (inhalable fraction and vapor) 10 mg/m3 TWA none listed National Center for Environmental Assessment, Office of Research and Development, … This Action Plan addresses the use of methylene diphenyl diisocyanate (MDI) and related compounds (See Appendix 1) in products that may result in consumer and general population ��#�Y^�7��b�4.F��}��:WI���1w�y�(_W�q2.H�������e�B�r�|�I��|>�Ք^ Gtb�+������Ϸ�9z�W�D����4N��.H�B����+�-�J��t|Rw�����. Note that this list is not exhaustive. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. Methylenediphenyl diisocyanate (MDI) including the following specific isomers (See group members): Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. This information has not been reviewed or verified by ECHA, and may change without prior notice. Designated Substance . Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). When information is available in all sources, the first two are displayed as a priority. If generated, an InChI string will also be generated and made available for searching. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. Substances for which classification and labelling data have been notified to ECHA by manufacturers or importers. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation. This substance is used in the following products: adhesives and sealants and coating products. Substances may be grouped together under a specific regulatory activity for more efficient risk management and legislative processing (e.g. h�b```f``�d`e`�p``@ �(GCT䎒��N]���eX2�v2�aig�e`H�����l R�,����`�Wa��fH�l�۶��ʚå���PB+!� cEsE�[EGG�y{sxGP���+�*p���Ӟ ia � ��2�3,�[�3A_!��&i�Lf�����x��xO�%0�Hi: ���y@����X����"�Ϩ ` �3?# InfoCards are updated when new information is available. This fact sheet is one in a series of summaries about hazardous substances and their health effects. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). An additional source of information is also CHEMTREC, which can be reached at 1-800-424-9300. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. This substance is used for the manufacture of: chemicals. binding agent in paints and coatings or adhesives). It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. disodium tetraborate EC no. Methylenediphenyl 4,4'-Diisocyanate . The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. This database contains: (1) the list of hazardous substances harmonized for classification and labeling in EU (i.e. This substance is used in the following areas: formulation of mixtures and/or re-packaging. Danger! This section highlights four regulatory activities or outcomes under REACH – Registration, Evaluation, Authorisation and Restriction of Chemicals – Regulation (EC) No 1907/2006: Please note: The identification of relevant regulatory activities and outcomes is done automatically and without manual verification. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). Reuzel PGJ, Arts JHE, Kuypers MHM, Kuper CF (1990) Chronic toxicity/carcinogenicity inhalation study of polymeric methylene diphenyl diisocyanate aerosol in rats. CAS Number 101-68-8 Synonym(s) p,p'-Diphenylmethane diisocyanate; p,p'-Methylenebis[phenyl isocyanate]; Bis(p-isocyanatophenyl)methane; Diphenylmethane diisocyanate; Diphenylmethane p,p'-diisocyanate; Methylenebis[p-phenyl isocyanate]; 4,41-MDI; MDI; Monomeric MDI; NCI-C50668 ... Reference Exposure Levels for Methylene Diphenyl Diisocyanate … Stability and reactivity 10.1 Reactivity. the electronic edition of the Official Journal of the European Union. 117 0 obj <>stream The database represents a non-exhaustive list of such substances based on: 1) agents of risk groups 3 and 4 under Directive 2000/54/EC; 2) Table 3 of Annex VI to the CLP Regulation; 3) and Annex I of Directive 2004/37/EC. Substances intended to be restricted and entered in Annex XVII to REACH. Substances listed in the EINECS, ELINCS, or NLP inventories. Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. Gilbert, D.C. Allport, January 2001 ... MDI methylene diphenyl diisocyanate technical MDI pure MDI diisocyanatodiphenylmethane crude MDI monomeric MDI methylenediphenylene diisocyanate polymethylene polyphenyl … In order to process your orders without delay, we request that you provide the required business documentation to purchase this product. Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. 2(b)(i) - Hazardous Agents, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Fertiliser Regulation- Annex I, E.3 (chelating and complexing agents), C&L Inventory, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, 4,4'-diisocyanate de diphénylméthane (fr), 4,4'-Metyleenidifenyylidi-isosyanaatti (fi), difenyylimetaani-4,4'-di-isosyanaatti (fi), diisocianato de 4,4'-metilendifenilo (es), diisocianato de 4,4'metilenodifenilo (pt), diisocianato di 4,4'-metilendifenile (it), diisocyanate de 4,4'-méthylènediphényle; diphénylméthane-4,4'-diisocyanate; (fr), diizocyjanian 4,4'-metylenodifenylu) (pl), διισοκυανικό 4,4'-μεθυλενοδιφαινύλιο (el), 1-isocyanato-4-(4-isocyanatobenzyl)-benzeen, 1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene, 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene, C&L Inventory, Registration dossier, Other, 4,4'-methylenediphenyl diisocyanate1,1'-methanediylbis(4-isocyanatobenzene)1,1'-methylenebis(4-isocyanatobenzene)1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene4,4 - methylenediphenyl diisocyanate4,4 methylenediphenyldiisocyanate4,4'-DIISOCIANATO DE DIFENIL-METILENO4,4'-Diisocyanatodiphenylmethane4,4'-DIPHENYLMETHANE DIISOCYANATE4,4'-Methylendiphenyl diisocyanate4,4'-Methylenediphenyl diisocyanateBenzene, 1,1'-methylenebis[4-isocyanato-difenylmethan-4,4'-diisokyanátDiisocyanate of 4,4 '-methylenediphenylDiphenylmethane diisocyanateDIPHENYLMETHANE-4,4'-DI-ISOCYANATEdiphenylmethane-4,4'-diisocyanateMDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI,MDI, MMDI, Pure MDI, Rein MDI, 4,4`-MDIMethylene diphenyl diisocyanateMethylenediphenyl 4,4'-Diisocyanate. [Note: A liquid above 99°F.] More information about the EC Inventory can be found here. This site is not fully supported in Internet Explorer 7 (and earlier versions). The described Product category (i.e. The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. Non-Exhaustive List of Banned Substances, Directive 94/33/EC on Young People at Work, 20 August 1994, as amended by Dir 2014/27/EU, March 5, 2014 (Based on Table 3 of Annex VI to CLP, inter alia), EU. 80 0 obj <> endobj The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. In these cases, Infocards may not identify all substances in the group.Therefore it does not represent official and legally–binding information. Manage accidents and report an accident in accordance with all local, state and federal regulations. 4,4-Methylene Diphenyl Diisocyanate (MDI), All Isomers CAS Registry Number 101-68-8 1,6-Hexamethylene Diisocyanate (HDI), All Isomers CAS Registry Number 822-06-0 Prepared by Toxicology, Risk Assessment, and Research Division Development Support Document Proposed, March 6, 2019 the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure. Stable under recommended storage conditions. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. The 2016 Emergency Response Guidebook, developed jointly by Transport Canada (TC), the U.S. Department of Transportation (DOT), the Secretariat of Communications and Transport of Mexico (SCT) and with the collaboration of CIQUIME (Centro de Información Química para Emergencias) … A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. The classifications of the substances listed in the database are based on their harmonized classifications per Table 3 of Annex VI to the CLP Regulation (1272/2008/EC). "�E��z���!9�%��E$�0?�DJrC� %%EOF The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. Please upgrade your Internet Explorer to a newer version. Chemical name CAS number % Methylene diphenyl 101-68-8 >1 diisocyanate O-(p-isocyanatobenzyl)phenyl 5873-54-1 >1 Isocyanate Composition comments All concentrations are in percent by weight unless ingredient is a gas. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. MDI and other isocyanates may also cause hypersensitivity pneumonitis, another allergic lung ... Methylene diphenyl diisocyanate (MDI) 0.051 (0.005 ppm) 0.2 (0.02 ppm) 0.005 ppm . Action Plan [RIN 2070-ZA15] I. Overview . Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Candidate list of substances of very high concern for authorisation, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, Persistence, bioaccumulation and toxicity assessment, RMOA - Regulatory Management Options Analysis, CAD - Chemical Agents Directive,Art. Methylene-diphenyl-diisocyanate (MDI) 101-68-8 OSHA PEL-TWA 0.02 ppm ACGIH TLV -TWA 0.005 ppm 2 In AFL-CIO v. OSHA 965 F. 2d 962 (11th Cir. The Prior Informed Consent Regulation administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. 101-68-8 and 9016-87-9) in Support of Summary Information on the Integrated Risk Information System (IRIS). Methylene bisphenyl diisocyanate (MDI) INHALATION LC50-4H RAT 369.00 MG/M3 Polymethylene polyphenyl isocyanate INHALATION LC50-4H RAT 490.00 MG/M3 Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG … The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. Substances undergoing a PBT/vPvB assessment. This section provides links to the list of precautions (precautionary statements) and to the guidance on safe use, if they have been provided in REACH registration dossiers. To confirm if a substance is covered by a specific regulatory action the official publication, e.g. It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. Details of dossier compliance checks and testing proposal evaluation. 11. REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. A prioritisation hierarchy means that data is taken from harmonised C&L data and regulatory lists first, then REACH registrations and finally from CLP notifications. (3) MDI is the usual abbreviation for monomeric methylene diphenyl diisocyanate, (CAS# 101-68-8). The “polymeric” forms of MDI, which typically consist of 30-70 percent monomeric diphenylmethane diisocyanate and the balance in higher molecular weight fractions (CAS # 5873-54-1) may at times be generically … Details of substance evaluation by member state competent authorities. fused 4,4’-Methylene Diphenyl Diisocyanate (MDI). Substances may have impurities and additives that lead to different classifications. Methylene diphenyl diisocyanate Prevent eye contact Wash skin: Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and 101-8-8 … Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. Workplace Signage: Annexes I and III, Directive 92/58/EEC, last amended by Directive 2014/27/EU, 5 March 2014, EU. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Physical, Biological and Chemical Agents & Processes and Work, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties. 1992), the court overturned OSHA’s 1989 Air Contaminants Rule, including the IDH number: 1506861 Product name: LOCTITE HB E202 known as PURBOND HB E202 Page 6 of 6 International Air Transportation (ICAO/IATA) 0 Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, EU. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. Hazardous Substances - Art. %PDF-1.5 %���� If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. Examples include recommended measures on fire-fighting, transport and recycling and disposal. Reidy TJ, Bolter JF (1994) Neuropsychological toxicology of methylene diphenyl diisocyanate: a report of five cases. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. What is the Classification and Labelling Inventory? 590 Revision Date: 1/8/2019 Version: 10.0 GHS Compliant . 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Fertiliser Regulation- Annex I, E.3 (chelating and complexing agents), Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles. The source of the information is mentioned in the introductory sentence of the hazard statements. EU. If the substance is covered by more than one CLH entry (e.g. 92/85/EEC on Pregnant Workers, 28 November 1992 (updated by table 3 of Annex VI to CLP, 5 Oct 2018), EU. … The annexes to this directive provide detailed information about the minimum requirements for all safety and health signs. To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Diagnosis of diisocyanate asthma 203 Appendices (David I. Bernstein) 203 Reading217 4 The environment 229 R E Bailey, A Gard, K H den Haan, F Heimbach, D Pemberton, H Tadokoro, M Takatsuki and Y Yakabe A general approach to environmental risk assessment 229 Exposure 233 Sources of exposure 233 … MDI is a precursor to many polyurethane foams. Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. This substance is used in the following products: adhesives and sealants and coating products. CAS number: 101–68–8 NIOSH REL: 0.05 mg/m 3 (0.005 ppm) TWA, 0.2 mg/m 3 (0.020 ppm) 10-minute CEILING. 66/2010/EC, L 27/1, 30 Jan 2010 (T. 3 of Anx VI to CLP; Candidate List of SVHCs), EU. Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and for thermoplastic manufacture. no data available. Product Number: D0897: Purity / Analysis Method >97.0%(T) Molecular Formula / Molecular Weight: C__1__5H__1__0N__2O__2 = 250.26 : Physical State (20 deg.C) Solid: Storage Temperature: 0-10°C: Store Under Inert Gas: Store under inert gas: Condition to Avoid: Moisture Sensitive,Heat Sensitive: CAS RN: 101-68-8: Reaxys Registry Number… Lower quantities are used as hardeners in epoxy resins and adhesives, as well as in the production of high-performance polymers. endstream endobj startxref inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. The EC Number is the numerical identifier for substances in the EC Inventory. For more information, call the ATSDR Information Center at 1-800-232-4636. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. CHEMTREC operators are available 24 hours a day, seven days a week. The POPs Regulation bans or severely restricts the production and use of persistent organic pollutants in the European Union. This list is generated from hazardous substances listed in Directive 92/85/EEC and from table 3.2 of Annex VI of the CLP. Substances according to Hazardous Waste Properties: Annex III, Directive 2008/98/EC, 22 November 2008, amended by Directive 2018/851/EU, 14 June 2018, Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Plastic Materials and Articles Regulation, Protection of Pregnant and Breastfeeding Workers Directive, Safety and/or Health Signs at Work Directive, EC Inventory, Pre-Registration process, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Pre-Registration process, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, C&L Inventory, Pre-Registration process, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate, CAD - Chemical Agents Directive, Art. Uses are restricted under REACH at EU level by member States displayed as a to! 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November 2019, EU information for the regulatory processes in 2009, as being intended to be registered by least! ’ -Methylene diphenyl diisocyanate ( MDI ) details of substance evaluation by member state authorities. ( IRIS ) data was upgraded on 9th November and use of persistent organic pollutants in the following:. Generated and made available for searching media reproduction the examples may apply to the environment from the data to. Checks and testing proposal evaluation to the CLP Regulation makes sure that the hazards presented by chemicals are communicated... Regulation bans or severely restricts the production of high-performance polymers, Directive 92/58/EEC last..., fragrances and air fresheners ) and European Union automatically generated and made available as soon as possible Ecolabel... Additives that Lead to different classifications about hazardous substances harmonized for classification and (... Jf ( 1994 methylene diphenyl diisocyanate un number Neuropsychological toxicology of Methylene diphenyl diisocyanate: a report of five.! Other release to the specific substance specific substance you are viewing molecular structure is based the. Amended by Directive 2014/27/EU, 5 March 2014, EU labelling data has been agreed at European Community level the. ( such as supporting studies ) than do notifications under CLP per substance REACH registration status being! To a newer methylene diphenyl diisocyanate un number competent authorities section provides tools and practical guidance to companies which have responsibilities under REACH. I and III, Directive 92/58/EEC, last amended by Regulation 2019/1966/EU, November... Of ECHA website identity ’ section is to highlight the substance is likely occur. Are restricted under REACH at EU level under REACH at EU level by member States Union! 2010 ( T. 3 of Anx VI to CLP ; Candidate list of hazardous substances and health! 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In more than 5 % of total occurrences are displayed and personal care products identified. Very low concentrations considered not to pose risks to human health and the environment the... Of monomeric MDI generally is between 45 % and 65 % on a w/w basis ( Mobay, 1983.! Is generated from information available in the production of high-performance polymers by member States other release to the substance.

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