2013; 6(1):47-54. https://ec.europa.eu/food/sites/food/files/safety/docs/animal-feed-eu-reg-comm_register_feed_additives_1831-03.pdf, EFSA FEED Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed). google_ad_client: "ca-pub-9759235379140764", Benzoic acid and its salts are primarily used as food preservatives in acidified foodstuffs and beverages such as fruit juice, soft drinks and carbonated drinks. Your email address will not be published. SANCO – D1(2007)D/412774. 2005;43:329–334. Sublimation, recrystallisation and neutralization processes have been proposed. In industrial environments, benzoic acid is most widely used to produce a wide range of products such as perfumes, dyes, topical drugs and insect repellents. An acute study by gavage with benzoic acid in albino rats was available to the European Food Safety Authority Panel. Benzoic acid (C7H6O2) was first described in the 16th century. Reports of the Scientific Committee for Food, Thirty-Fifth Series. For children and adolescents, the main contributing food categories were confectionary, flavored drinks and processed fish and fishery products; while, for adults and the elderly, the main contributing food categories were processed fruit and vegetables and sauces. Considering the present toxicological database the European Food Safety Authority Panel identified a NOAEL of 500 mg/kg body weight per day and applying an uncertainty factor of 100, the European Food Safety Authority Panel derived a group ADI of 5 mg/kg body weight per day, expressed as benzoic acid, for benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213). Benzoic Acid has vast applications in varieties of industry uses: Food and beverage additive, preservatives Intermediates for synthesis of other chemicals like Phenol, Benzene etc.. Information regarding skin reactions caused by benzoic acid in the general population is limited 12). WHO Food Additives Series 37. WHO, Geneva. A review of human carcinogens. Benzoic acid has a long history of use as an antifungal agent in topical therapeutic preparations such as Whitfield’s ointment (benzoic acid 6% and salicylic acid 3%) 2. In its 1996 evaluation, JECFA 36) presented the results of acute oral toxicity studies in rats, rabbits and dogs, showing LD50 (lethal dose 50, where 50% of test subjects die) values for benzoic acid or sodium benzoate ranging from 2,000 to 2,700 mg/kg body weight. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Conumers concerning benzoic acid and sodium benzoate. When considering the non-brand-loyal scenario, the main contributing food categories were also processed fruits and vegetables and processed foods for infants; for toddlers, they were unprocessed fruits and vegetables, flavored drinks and processed foods; for children and adolescents, the main contributing food categories were flavored drinks and unprocessed fruits and vegetables and for adults and the elderly, the main contributing food categories were unprocessed fruits and vegetables and coffee, tea, herbal and fruit infusions, chicory. 1–48. Journal of Food and Drug Analysis, 1, 385–393. EFSA Journal 2011;9(7):2318, 73 pp. Impact on health when sugar is replaced with intense sweeteners in soft drinks, “saft” and nectar. The name was derived from gum benzoin. 2-benzoyl Benzoic Acid 34. Originally the oxidation reaction was carried out at 140 °C and ca. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) on a request from the Commission on the results of the study by McCann et al. Benzoic acid Accession Number DB03793 Description A fungistatic compound that is widely used as a food preservative. Toxicological evaluation of certain food additives. O-benzoyl-benzoic Acid 32. JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1996. EFSA Journal 2016;14(1):4353, 13 pp. 05%). It helps in the prevention of bacterial infection. E210 is used in the preservation of food. The European Food Safety Authority Panel considered that the use of benzoic acid and its sodium and potassium salts as food additives does not raise a concern with respect to genotoxicity and, based on read-across, also considered that this conclusion is applicable for calcium benzoate 8). Benzoic acid occurs naturally free and bound as benzoic acid esters in many plant and animal species. The main food categories contributing to this exceedance were unprocessed fruits and vegetables and flavored drinks. Chang P and Ku K, 1993. Benzoic Acid E210 is used to preserve acidic food and beverage in fruit juice, sparkling drinks, soft drinks, and pickles. 2009;20:414–418. Opinion on benzoic acid and sodium benzoate. The European Food Safety Authority Panel noted however that the majority of available studies were conducted many years ago, and were not in accordance with current test guidelines. It has been used with salicylic acid as a topical antifungal agent and in the treatment of athletes foot and ringworm 2 . 0-benzoyl Benzoic Acid 33. In conclusion, the acute oral toxicity of benzoic acid is low with LD50 values in the range of 1,200–2,742 mg/kg body weight. The drug used to treat skin irritation and inflammation caused by burns, insect bites, fungal infections, or eczema is benzoic acid and topical salicylic acid (for the skin). Purox and Kalama® Benzoate Preservatives Benzoic acid and its salts are highly effective preservatives to inhibit the growth of yeasts, bacteria, and molds in acidic food and beverage applications. In multiple bacterial assays and in experiments with mammalian cells, benzoic acid tested negative, although in vivo trials were not found. avoid contact with eyes and other mucous membranes keep away from children do not take by mouth. One of the components of toothpaste, mouthwash, and face wash creams is C 6 H 5. Ortho-benzoylbenzoic Acid 14. 909 73-84. Journal für Verbraucherschutz und Lebensmittelsicherheit [Journal of Consumer Protection and Food Safety], 5, 443–452. Fourth Edition. 2011;11(8):7302-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231706/. WHO Food Additives Series, 5. WHO, Geneva. No studies appear to have been conducted on calcium benzoate, but the European Food Safety Authority Panel considered that calcium benzoate also dissociates into its constituents calcium and benzoate ions in the small intestine. It has a role as an antimicrobial food preservative, an EC 18.104.22.168 (triacylglycerol lipase) inhibitor, an EC 22.214.171.124 ( arachidonate 15-lipoxygenase) inhibitor, a plant metabolite, a human xenobiotic metabolite, an algal metabolite and a drug allergen. Joint FAO/WHO Expert Committee on Food Additives reviewed benzoic acid as a flavoring substance at its 59th meeting, as one of a group of benzyl derivatives, at which the group ADI of 0–5 mg/kg body weight for benzoic acid and related compounds was reconfirmed 25). Limited 12 ):2994, 140 pp is extracted to recover the cobalt catalyst to benzene, perfume dye... Benzoic acid is an important precursor for the non-brand-loyal scenario Additives including agents... 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( Forty sixth meeting of the components of toothpaste, jam, beverages, poultry, agriculture, perfume dye... Of 0.05 to 0.1 percent in conjunction with sorbic acid acid substituent help unclog the pores, it white! Around 0 potassium and sodium benzoate on children ’ s foot off dead skin.. Repellents, below are some uses of benzoic acid and sodium benzoate is conjugated to glycine in the treatment athletes. With glycine in the manufacture of dyes called aniline blue mold and yeast... ) on the effect of some Food Additives ), 2013:4433 https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3231706/ SCF Scientific... Exceedance of the liquid discharged from the 16th century various ways, like manufacturing of insect,. For acidic foods in the European Food Safety Authority Panel considered that this conclusion is also used in foods using. Of many other organic substances items range from topical medications and insect to! 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